DNAマイクロアレイを用いた Mycobacterium leprae の迅速薬剤感受性試験法 [in Japanese] DNA microarray based rapid drug susceptibility test for Mycobacterium leprae [in Japanese]
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Antibiotic susceptibility test of <i>Mycobacterium leprae</i> still relies on the time consuming methods based on the growth of <i>M. leprae</i> in the mouse footpad. Thus, the establishment of a rapid, simple and reliable method for the detection of drug-resistant <i>M. leprae</i> is one of the most urgent subjects in the treatment of leprosy patients. Recently, many data on the mutation of specific genes correlating with drug resistance have been accumulated. Application of these data permit the establishment of new gene diagnostic methods for drug susceptibility test of leprosy.<br>In this paper, the method using the low density oligonucleotide array that enables the detection of base substitutions involved in resistance against anti-leprosy drugs on a single platform was discussed. The low density oligonucleotide array described in this paper will open the new perspectives in terms of patient management for leprosy with low cost requirement.
- Japanese journal of leprosy
Japanese journal of leprosy 75(3), 271-277, 2006-10-01
Japanese Leprosy Association