DNAマイクロアレイを用いた Mycobacterium leprae の迅速薬剤感受性試験法 DNA microarray based rapid drug susceptibility test for Mycobacterium leprae

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著者

    • 鈴木 定彦 SUZUKI Yasuhiko
    • 北海道大学人獣共通感染症リサーチセンター国際疫学部門 Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control
    • 松岡 正典 MATSUOKA Masanori
    • 国立感染症研究所ハンセン病研究センター生体防御部 Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases

抄録

Antibiotic susceptibility test of <i>Mycobacterium leprae</i> still relies on the time consuming methods based on the growth of <i>M. leprae</i> in the mouse footpad. Thus, the establishment of a rapid, simple and reliable method for the detection of drug-resistant <i>M. leprae</i> is one of the most urgent subjects in the treatment of leprosy patients. Recently, many data on the mutation of specific genes correlating with drug resistance have been accumulated. Application of these data permit the establishment of new gene diagnostic methods for drug susceptibility test of leprosy.<br>In this paper, the method using the low density oligonucleotide array that enables the detection of base substitutions involved in resistance against anti-leprosy drugs on a single platform was discussed. The low density oligonucleotide array described in this paper will open the new perspectives in terms of patient management for leprosy with low cost requirement.

収録刊行物

  • 日本ハンセン病学会雑誌 = Japanese journal of leprosy  

    日本ハンセン病学会雑誌 = Japanese journal of leprosy 75(3), 271-277, 2006-10-01 

    Japanese Leprosy Association

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各種コード

  • NII論文ID(NAID)
    10018265493
  • NII書誌ID(NCID)
    AN10559906
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    13423681
  • データ提供元
    CJP書誌  J-STAGE 
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