Polymorphisms of the prion protein gene (PRNP) in Hanwoo (Bos taurus coreanae) and Holstein cattle

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Polymorphisms in the prion protein gene (<i>PRNP</i>) in humans and sheep correlate with susceptibility to transmissible spongiform encephalopathies (TSEs). Bovine spongiform encephalopathy (BSE) has been reported in British and Japanese cattle; it has occurred thus far in Holstein cattle. BSE in Hanwoo (<i>Bos taurus coreanae</i>) cattle has not been diagnosed up to now. To characterize the bovine <i>PRNP</i> polymorphisms in Korean cattle, we analyzed the open reading frame (ORF) of <i>PRNP</i> in 120 Hanwoo (beef) cattle and 53 Holstein (dairy) cattle. Three polymorphisms were found, the third position of codon 78 (G→A), the third position of codon 192 (C→T), and the deletion of a single octa-repeat. An analysis of codon 78 revealed no difference in the genotype (<i>P </i>= 0.2026) or allele (<i>P </i>= 0.7180) frequencies between Hanwoo and Holstein animals. However, there were significant differences in the genotype (P < 0.0001) and allele (P < 0.0001) frequencies at <i>PRNP </i>codon 192 between Hanwoo and Holstein animals. The rate of Holstein animals with deletion of a single octa-repeat was 91.5% undeleted homozygotes, 8.5% heterozygotes (with R3 deletion), and 0% deleted homozygotes. However, none of the 120 Hanwoo animals had any octa-repeat deletions. The genotype (<i>P</i> < 0.0001) and allele (<i>P</i> < 0.0001) frequencies of a single octa-repeat-deletion were also significantly different between Hanwoo and Holstein animals.<br>

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  • Genes & genetic systems  

    Genes & genetic systems 80(4), 303-308, 2005-08-25 

    The Genetics Society of Japan

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各種コード

  • NII論文ID(NAID)
    10018280300
  • NII書誌ID(NCID)
    AA11077421
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13417568
  • NDL 記事登録ID
    7681558
  • NDL 雑誌分類
    ZR1(科学技術--生物学)
  • NDL 請求記号
    Z53-W539
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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