高質ナノ結晶作製で実現したX線1分子計測 X-ray Single Molecular Detection System Using High-Quality Nanocrystals
Recently, we succeeded<I>in vitro</I>time-resolved X-ray observations of picometer-scale slow Brownian motions of individual protein molecules in aqueous solutions. In this new single molecular detection system, which we call Diffracted X-ray Tracking (DXT), we observed the rotating motions of an individual nanocrystal, which is labeled to the specific site in individual protein molecules, using time-resolved Laue diffraction. DXT can monitor dynamics of the individual molecules or specific sites in individual single protein molecules. Now, we try to observe individual DNA molecules, myosin head molecules, denatured proteins, protein membranes. One of the most important technologies in DXT is fabrications of high-quality gold nanocrystals under high pressure conditions.
日本結晶学会誌 47(5), 354-360, 2005-10-30
The Crystallographic Society of Japan