X-ray Single Molecular Detection System Using High-Quality Nanocrystals

• SASAKI Yuji C.

  SPring-8/JASRI Biomedical Group, JST/CREST Sasaki-team

Bibliographic Information

Other Title

• 高質ナノ結晶作製で実現したＸ線１分子計測
• サイキン ノ ケンキュウ カラ コウシツ ナノ ケッショウ サクセイ デ ジツゲン シタ Xセン 1 ブンシ ケイソク

Abstract

Recently, we succeededin vitrotime-resolved X-ray observations of picometer-scale slow Brownian motions of individual protein molecules in aqueous solutions. In this new single molecular detection system, which we call Diffracted X-ray Tracking (DXT), we observed the rotating motions of an individual nanocrystal, which is labeled to the specific site in individual protein molecules, using time-resolved Laue diffraction. DXT can monitor dynamics of the individual molecules or specific sites in individual single protein molecules. Now, we try to observe individual DNA molecules, myosin head molecules, denatured proteins, protein membranes. One of the most important technologies in DXT is fabrications of high-quality gold nanocrystals under high pressure conditions.

Journal

• Nihon Kessho Gakkaishi

  Nihon Kessho Gakkaishi 47 (5), 354-360, 2005

  The Crystallographic Society of Japan

Details

• CRID: 1390282679064364800
• NII Article ID: 10018280673
• NII Book ID: AN00188364
• DOI: 10.5940/jcrsj.47.354
• ISSN: 18845576
• ISSN: 03694585
• NDL BIB ID: 7717733
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7717733
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed