書誌事項
- タイトル別名
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- Efficacy and safety of Itraconazole injections and capsules in deep mycosis uncontrolled multicenter open-label trial
- Itraconazole-Deep Mycosis Research Group
- Itraconazole深在性真菌症研究班
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We investigated the efficacy and safety of Itraconazole (ITCZ) in patients with deep mycosis, evaluating intravenous injection of ITCZ (200 mg) for 2 weeks (twice a day for the first two days, then once a day for the remaining 12 days) prior to the oral administration of ITCZ capsules (200 mg) twice a day.<BR>Total efficacy was 67.7%(21/31 cases). The efficacy in aspergillosis patients was 57.9%(11/19 cases), 71.4%(5/7) in candidiasis patients, and 100%(5/5) in cryptococcosis patients. No difference was seen in the incidence of adverse events in injection and capsule administration, and most observed adverse events of ITCZ were already known.<BR>ITCZ plasma trough concentration after two days of injection (200 mg twice a day) reached a level (811.3±316.0 ng/mL, Mean ± S. D., n=42) efficient in treating conditions caused by primary underlying mycoses (Aspergillus, Candida, Cryptococcus), and high plasma was maintained continuously through administration of ITCZ capsules.<BR>ITCZ injection reaches efficient plasma concentration rapidly compared to ITCZ capsules. ITCZ injection is effective for serious and acute conditions but the approved maximum dose of 200 mg/day for ITCZ capsules is not effective in treating deep mycosis.<BR>Plasma concentration reached by ITCZ injection is continuously maintained through the administration of ITCZ capsules (200 mg, twice a day). We concluded that the first 2 weeks of injection prior to oral administration is effective in treating deep mycosis.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 54 (Supplement1), 32-47, 2006
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681267280384
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- NII論文ID
- 10018303691
- 130004298314
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可