筋上皮腫および悪性筋上皮腫症例の免疫組織学的検討 Immunohistochemical Features of Myoepithelioma and Myoepithelial Carcinoma
Myoepithelioma (ME) and myoepithelial carcinoma (MEC) are both rare salivary neoplasms. We report cases of ME and MEC. The ME case was a 36-year-old female complaining of a painless mass in the parotid gland present for four years. The MEC case was a 50-year-old male suffering from nasal obstruction caused by the recurrence of a previous pleomorphic adenoma which arose from the hard palate, extending to the nasal cavity. Both tumors were surgically removed. Histopathological examination demonstrated that both tumors consisted of spindle and plasmacytoid cells, and, in the MEC case, infiltrative growth and cytologic abnormalities. Immunohistochemical study revealed positive reactions for SMA, vimentin, S-100 protein, and CK-14 in both tumor cell types, and significantly higher expressions of p53 and Ki-67 in the MEC case.
耳鼻咽喉科臨床 99(11), 945-949, 2006-11-01
The Society of Practical Otolaryngology