プロポフォール薬物動態と心拍出量 Influence of Atropine on the Dose Requirements of Propofol in Humans

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著者

    • TAKIZAWA Eri
    • Department of Anesthesiology, Graduate School of Medicine, Gunma University
    • TAKIZAWA Daisuke
    • Department of Anesthesiology, Graduate School of Medicine, Gunma University
    • AL-JAHDARI Wael S.
    • Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University
    • MIYAZAKI Mitsue
    • Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University
    • NAKAMURA Katsunori
    • Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University
    • YAMAMOTO Koujirou
    • Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University
    • HORIUCHI Ryuya
    • Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University
    • HIRAOKA Haruhiko
    • Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center

抄録

  <b>Objective:</b> The purpose of this study was to evaluate the effect of atropine on the dose requirement of propofol for induction of anesthesia and propofol concentrations during continuous infusion.<br>   <b>Methods:</b> Study 1: Forty patients were randomly allocated to the control or atropine groups. Induction of anesthesia commenced 3 min following the administration of 0.9% saline or atropine (0.01 mg kg<sup>-1</sup>), using a Diprifuser set to achieve propofol concentration of 6.0 μg mL<sup>-1</sup>. The primary end point was the propofol dose per kg at the moment of loss of response to a command. Study 2: Fifteen patients undergoing elective surgery were enrolled. Propofol was administered to all subjects <i>via</i> target-controlled infusion to achieve a propofol concentration at 2.0 μg mL<sup>-1</sup> after intubation. Before and after administration of atropine (0.01 mg kg<sup>-1</sup>), cardiac output (CO) was measured using indocyanine green as an indicator and blood propofol concentration was determined using high-performance liquid chromatography.<br>   <b>Results:</b> Study 1: The propofol dose for each group was 2.22±0.21 mg kg<sup>-1</sup> for control group and 2.45±0.28 mg kg<sup>-1</sup> for atropine, respectively (p=0.014). Study 2: After the administration of atropine, CO was significantly increased from 4.28±0.83 to 5.76±1.55 l min<sup>-1</sup> (p<0.0001). Propofol concentration was significantly decreased from 2.12±0.28 to 1.69±0.27 μg mL<sup>-1</sup> (p<0.0001).<br>   <b>Conclusions:</b> Following the administration of atropine, the propofol requirements for the induction of anesthesia were increased and propofol concentrations were decreased during continuous infusion by the administration of atropine.<br>

収録刊行物

  • Drug metabolism and pharmacokinetics  

    Drug metabolism and pharmacokinetics 21(5), 384-388, 2006-10-30 

    The Japanese Society for the Study of Xenobiotics

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各種コード

  • NII論文ID(NAID)
    10018307008
  • NII書誌ID(NCID)
    AA1162652X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13474367
  • データ提供元
    CJP書誌  J-STAGE 
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