Influence of Atropine on the Dose Requirements of Propofol in Humans

• TAKIZAWA Eri

  Department of Anesthesiology, Graduate School of Medicine, Gunma University

• TAKIZAWA Daisuke

  Department of Anesthesiology, Graduate School of Medicine, Gunma University Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center

• AL-JAHDARI Wael S.

  Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University

• MIYAZAKI Mitsue

  Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University

• NAKAMURA Katsunori

  Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University

• YAMAMOTO Koujirou

  Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University

• HORIUCHI Ryuya

  Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University

• HIRAOKA Haruhiko

  Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center

Abstract

  Objective: The purpose of this study was to evaluate the effect of atropine on the dose requirement of propofol for induction of anesthesia and propofol concentrations during continuous infusion.<br>   Methods: Study 1: Forty patients were randomly allocated to the control or atropine groups. Induction of anesthesia commenced 3 min following the administration of 0.9% saline or atropine (0.01 mg kg^-1), using a Diprifuser set to achieve propofol concentration of 6.0 μg mL^-1. The primary end point was the propofol dose per kg at the moment of loss of response to a command. Study 2: Fifteen patients undergoing elective surgery were enrolled. Propofol was administered to all subjects via target-controlled infusion to achieve a propofol concentration at 2.0 μg mL^-1 after intubation. Before and after administration of atropine (0.01 mg kg^-1), cardiac output (CO) was measured using indocyanine green as an indicator and blood propofol concentration was determined using high-performance liquid chromatography.<br>   Results: Study 1: The propofol dose for each group was 2.22±0.21 mg kg^-1 for control group and 2.45±0.28 mg kg^-1 for atropine, respectively (p=0.014). Study 2: After the administration of atropine, CO was significantly increased from 4.28±0.83 to 5.76±1.55 l min^-1 (p<0.0001). Propofol concentration was significantly decreased from 2.12±0.28 to 1.69±0.27 μg mL^-1 (p<0.0001).<br>   Conclusions: Following the administration of atropine, the propofol requirements for the induction of anesthesia were increased and propofol concentrations were decreased during continuous infusion by the administration of atropine.<br>

Journal

• Drug Metabolism and Pharmacokinetics

  Drug Metabolism and Pharmacokinetics 21 (5), 384-388, 2006

  The Japanese Society for the Study of Xenobiotics

Keywords

• pharmacokinetics
• cardiac output
• concentration

Details

• CRID: 1390001205179659008
• NII Article ID: 10018307008
• NII Book ID: AA1162652X
• DOI: 10.2133/dmpk.21.384
• ISSN: 18800920
• ISSN: 13474367
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715307096?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715307096?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2007102256
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed