"F344"の二大亜系統, F344/DuとF344/Nの下顎骨の特性比較 Comparison of Rat Mandible Bone Characteristics in F344 Substrains, F344/Du and F344/N

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著者

    • 田中 愼 TANAKA Shin
    • 国立長寿医療センター・加齢動物育成室 Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS)
    • 桑原 佐知 KUWAHARA Sachi
    • 国立長寿医療センター・加齢動物育成室 Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS)
    • 大野 民生 OHNO Tamio
    • 名古屋大学大学院医学研究科 Division of Experimental Animals,Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University
    • 長屋 政博 NAGAYA Masahiro
    • 国立長寿医療センター・リハビリテーション科 Department of Rehabilitation, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)
    • 中村 康典 NAKAMURA Yasunori
    • 国立長寿医療センター・先端医療部・口腔外科 Division of Oral and Dental Surgery, Department of Advanced Medicine, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)
    • 角 保徳 SUMI Yasunori
    • 国立長寿医療センター・先端医療部・口腔外科 Division of Oral and Dental Surgery, Department of Advanced Medicine, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)

抄録

The characteristics of the mandible bone were compared through DXA methods between two major substrains of F344 rats, F344/DuCrlCrlj and F344/NSlc at around 60 days of age. Since these two substrains are clearly different in survival and mandible morphology, some genetic differences are supposed to exist. In contrast to a previous microsatellite analysis, clear and significant differences were detected in the body and mandible weights, the mandible bone mineral contents (BMC), bone area (AREA), bone mineral density (BMD) and bone mineral ratio (BMR), between F344/DuCrlCrlj and F344/NSlc, with the mandible molar teeth intact in the bone. Thus, care is needed in the experimental use of these substrains, as results may differ between them. The newly proposed parameter, BMR, may especially contribute to the comparison of bone characteristics among species.<br>

収録刊行物

  • Experimental animals  

    Experimental animals 55(5), 415-418, 2006-10-01 

    Japanese Association for Laboratory Animal Science

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各種コード

  • NII論文ID(NAID)
    10018307750
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13411357
  • NDL 記事登録ID
    8089625
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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