Comparison of Rat Mandible Bone Characteristics in F344 Substrains, F344/Du and F344/N

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  • TANAKA Shin
    Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS)
  • KUWAHARA Sachi
    Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS) Department of Anatomy, Hyogo College of Medicine
  • NISHIJIMA Kazutoshi
    Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS)
  • OHNO Tamio
    Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University
  • NAGAYA Masahiro
    Department of Rehabilitation, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)
  • NAKAMURA Yasunori
    Division of Oral and Dental Surgery, Department of Advanced Medicine, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)
  • SUMI Yasunori
    Division of Oral and Dental Surgery, Department of Advanced Medicine, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)
  • MIYAISHI Osamu
    Chubu Rosai Hospital
  • AOYAMA Hiroaki
    Institute for Environmental Toxicology
  • GOTO Nobuo
    Japanese Society for Laboratory Animal Resources

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Abstract

The characteristics of the mandible bone were compared through DXA methods between two major substrains of F344 rats, F344/DuCrlCrlj and F344/NSlc at around 60 days of age. Since these two substrains are clearly different in survival and mandible morphology, some genetic differences are supposed to exist. In contrast to a previous microsatellite analysis, clear and significant differences were detected in the body and mandible weights, the mandible bone mineral contents (BMC), bone area (AREA), bone mineral density (BMD) and bone mineral ratio (BMR), between F344/DuCrlCrlj and F344/NSlc, with the mandible molar teeth intact in the bone. Thus, care is needed in the experimental use of these substrains, as results may differ between them. The newly proposed parameter, BMR, may especially contribute to the comparison of bone characteristics among species.<br>

Journal

  • Experimental Animals

    Experimental Animals 55 (5), 415-418, 2006

    Japanese Association for Laboratory Animal Science

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