Morphometric Comparison of the Rat Mandible in F344 Substrains, F344/Du and F344/N

• TANAKA Shin

  Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS)

• KUWAHARA Sachi

  Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS) Department of Anatomy, Hyogo College of Medicine

• NISHIJIMA Kazutoshi

  Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS)

• NAKAMURA Yasunori

  Division of Oral and Dental Surgery, Department of Advanced Medicine, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)

• SUMI Yasunori

  Division of Oral and Dental Surgery, Department of Advanced Medicine, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology (NCGG)

• OHNO Tamio

  Division of Experimental Animals, Center for Promotion of Medical, Research and Education, Graduate School of Medicine, Nagoya University

• GOTO Nobuo

  Japanese Society for Laboratory Animal Resources

Abstract

The shape of the mandible was compared by morphometric methods to ascertain the genetic differences between two substrains of F344 rats, F344/DuCrlCrlj and F344/NSlc. Since these two substrains are clearly different in survival and the incidence of age associated disorders; thus, some genetic differences are suggested to be present between them. Although previous microsatellite analysis did not detect any differences between the two F344 substrains, the present study clearly detected interesting differences in the mandible morphology. At 2 months of age, the F344/Du mandible was characterized by a larger size, especially in length, than the F344/N mandible. The shape of the mandible seemed to be more variable in F344/N. This clear substrain difference suggests the importance of the substrain recognition in F344 rats, especially in experimental usage.<br>

Journal

• Experimental Animals

  Experimental Animals 55 (5), 433-438, 2006

  Japanese Association for Laboratory Animal Science

Keywords

• F344/Du
• F344/N
• mandible
• morphometry
• substrain difference

Details

• CRID: 1390282680023827456
• NII Article ID: 130000068074
• NII Article ID: 10018307821
• NII Book ID: AA11032321
• DOI: 10.1538/expanim.55.433
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL BIB ID: 8089646
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8089646
• Web Site: http://www.jstage.jst.go.jp/article/expanim/55/5/55_5_433/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007141905
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed