Diffuse Alveolar Lesion in BALB/c Mice Induced with Human Reovirus BYD1 Strain and its Potential Relation with SARS

この論文にアクセスする

この論文をさがす

著者

    • He Cheng HE Cheng
    • Laboratory Animal Institute, College of Veterinary Medicine, China Agricultural University
    • Yang Qi YANG Qi
    • Laboratory Animal Institute, College of Veterinary Medicine, China Agricultural University
    • PANG Wanyong
    • Laboratory Animal Institute, College of Veterinary Medicine, China Agricultural University
    • YANG Jianmin
    • Laboratory Animal Institute, College of Veterinary Medicine, China Agricultural University
    • ZHU Hong
    • Microbiology and Epidemiology Institute, Academy of Military Medical Science
    • DUAN Qing
    • Microbiology and Epidemiology Institute, Academy of Military Medical Science

抄録

The objective of this study was to investigate the pathogenicity and associated lesions of a new reovirus (ReoV) isolated from patients with Severe Acute Respiratory Syndrome (SARS) in China. Twenty-five four-week-old <i>BALB/c</i> female mice inoculated intranasally with either ReoV (strain BYD1) alone, or ReoV combined with SARS-CoV (strain BJF) displayed ejecting fur and loss of body weight compared with control animals. ReoV and SARS-CoV were isolated from most postmortem tissues. The histopathological features of ReoV infected animals consisted of diffuse alveolar damage, with scattered hemorrhage, hyaline membrane formation and interstitial pneumonia. A typical type II pneumocyte hyperplasia and fibrogranulomatous tissue formation in the alveolar septae were observed both in the animals inoculated simultaneously with these two viruses and in the animals inoculated firstly with SARS-CoV, followed by ReoV. The animals inoculated firstly with ReoV, followed with SARS-CoV displayed scattered hemorrhage in the alveolar septa. Furthermore, other lesions in above two combination groups included depletion of lymphocytes in the germinal center of lymph nodes in the lung hilus and the spleen, hemorrhagic necrosis in white pulp of spleen, hydroid degeneration, and fatty degeneration in the liver and kidney. Mice induced with SARS-CoV alone did not display clinical signs, characteristically hyaline membrane formation, hemorrhage and early pulmonary fibrosis in lung tissue. This study demonstrated that the newly isolated ReoV might be a virulent pathogen for BALB/c mice. Mice infected firstly with SARS-CoV, followed with ReoV developed a typical diffuse alveolar lesion.<br>

収録刊行物

  • Experimental animals  

    Experimental animals 55(5), 439-447, 2006-10-01 

    Japanese Association for Laboratory Animal Science

参考文献:  18件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10018307831
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13411357
  • NDL 記事登録ID
    8089655
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ