Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus

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  • SUZUKI Daisuke
    Laboratory of Animal Management & Resources, School of Bio-Agricultural Sciences Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University
  • MURATA Yoshiharu
    Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University
  • ODA Sen-ichi
    Laboratory of Animal Management & Resources, School of Bio-Agricultural Sciences

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The house musk shrew (Suncus murinus), or suncus, is a unique experimental mammal that is cold intolerant. However, even basic knowledge of brown adipose tissue (BAT), which is important for non-shivering thermogenesis (NST), is minimal. Therefore, we exposed suncus for 18 days to mild cold temperatures (8-14°C) and/or a high-fat diet, which are factors that increase NST, and measured two mRNAs that are critical for NST in BAT, uncoupling protein 1 (Ucp1) and type II 5'-deiodinase (D2). Neither mild cold exposure nor a high-fat diet alone induced up-regulation of the mRNAs. However, combinations of cold exposure and high-fat diet significantly increased both mRNAs. Therefore, cold intolerance in suncus may be partly caused by dietary components.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 55 (5), 467-471, 2006

    公益社団法人 日本実験動物学会

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