アザシクロファンを分子基盤とした水溶性ホストの合成とゲストデリバリー Synthesis of Water-soluble Azacyclophane Hosts as a Guest-delivering Carrier

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Various water-soluble azacyclophanes have been prepared and exhibited the following unique functions with regard to supramolecular functions in water : (1) The water-soluble supramolecular azacyclophanes composed of an adamantly-appended macrocyclic cyclophane with maltosyl-α-CD demonstrated the potentiality as hosts as well as transporters. (2) The water-soluble bis (cyclophane), tris (cyclophane), and pentakis (cyclophane) were synthesized on the basis of a molecular design that allows the connection of two, three, and five azacyclophanes, respectively. The guest-binding affinity of the present multi (cyclophane) s toward hydrophobic dyes was much enhanced, reflecting multivalency effects in macrocycles. (3) A new convenient strategy for the active sitedirected chemical modification of a lectin surface was demonstrated by using the water-soluble saccharide cyclophane. (4) In addition, a cyclophane-based resorcinarene tetramer, which is constructed with a tetraaza [6.1.6.1] paracyclophane and four resorcinarenes bearing hepta (carboxylic acid) residues that connect the macrocycle through amide linkages, was prepared. The cyclophane-based tetra (resorcinarene) acted as a host for both hydrophobic molecular guests and histone through hydrophobic and electrostatic interactions, respectively.

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  • 有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN  

    有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 64(10), 1041-1048, 2006-10-01 

    The Society of Synthetic Organic Chemistry, Japan

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各種コード

  • NII論文ID(NAID)
    10018311599
  • NII書誌ID(NCID)
    AN0024521X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00379980
  • NDL 記事登録ID
    8536451
  • NDL 雑誌分類
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL 請求記号
    Z17-256
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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