ウレア, チオウレア, グアニジンを用いた水素結合型分子認識 [in Japanese] Hydrogen Bonding-Based Molecular Recognition by Urea, Thiourea and Guanidine [in Japanese]
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Vast number of valuable metal catalyzed reactions has been developed to date. One of the important roles of the metals is the activation of an electrophile as a Lewis acid. On the other hand, due to environmental and economical demands, metal-free reactions have been attracting much attention. In this review, reactions catalyzed by urea, thiourea and guanidine are introduced. These catalysts have more than two active hydrogens, which can activate an electrophile through double hydrogen bonding. High enantioselectivity is achieved by tuning of their side chains.
- J. Synth. Org. Chem. Jpn.
J. Synth. Org. Chem. Jpn. 64(10), 1073-1074, 2006-10-01
The Society of Synthetic Organic Chemistry, Japan