Observation of Sequential Electrophilic Substitution of Bromothiophene and Immediate Reductive Elimination of Arylpalladium Complexes
Access this Article
Search this Article
The reaction of aryl(iodo)palladium(II)(bpy) complex with 2,3-dibromothiophene in the presence of AgNO<SUB>3</SUB>/KF as an activator induces CH arylation in 64–78% yields. These results suggest that palladium-catalyzed CH arylation of bromothiophene derivatives proceeds through the electrophilic substitution of aryl(iodo)palladium(II) complex triggered by AgNO<SUB>3</SUB>/KF to form the aryl(thienyl)palladium(II) complex, which readily undergoes reductive elimination to give the CH arylation product.
- Chemistry Letters
Chemistry Letters 35(10), 1100-1101, 2006-10-05
The Chemical Society of Japan