Enhanced Sensitivity of a Surface-plasmon-resonance (SPR) Sensor for 2,4-D by Controlled Functionalization of Self-assembled Monolayer-based Immunosensor Chip

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著者

    • KIM Sook Jin
    • Interdisciplinary Graduate School of Engineering Sciences, Kyushu University
    • MIURA Norio
    • Interdisciplinary Graduate School of Engineering Sciences, Kyushu University

抄録

A highly sensitive SPR immunosensor has been fabricated by covalent binding of a protein conjugate of 2,4-D (2,4-D-BSA) on SAM of 3-mercaptopropionic acid. With indirect inhibition immunoassay, it demonstrated a low detection limit of 0.1 ppb 2,4-D. Taking advantage of the combination of the SAM technique and immobilization of 2,4-D-BSA at controlled surface coverage, a remarkable enhancement of the low detection limit by 10-fold to 10 ppt with no use of any labels was demonstrated, while keeping the response time constant at 4 min.

収録刊行物

  • Chemistry letters  

    Chemistry letters 35(10), 1132-1133, 2006-10-05 

    The Chemical Society of Japan

参考文献:  12件

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各種コード

  • NII論文ID(NAID)
    10018323070
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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