A New Physiologically Based Pharmacokinetic Analysis for In Vivo Organ Disposition of Nitroxyl Spin Probes in Mice as Measured by Multisite Detection L-band ESR (MSD-LESR)

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著者

    • KAMATARI Masayuki
    • Department of Analytical Bioinorganic Chemistry, Kyoto Pharmaceutical University
    • YASUI Hiroyuki
    • Department of Analytical Bioinorganic Chemistry, Kyoto Pharmaceutical University
    • NAKAMURA Masahiro
    • Department of Analytical Bioinorganic Chemistry, Kyoto Pharmaceutical University
    • OGATA Tateaki
    • Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University
    • SAKURAI Hiromu
    • Department of Analytical Bioinorganic Chemistry, Kyoto Pharmaceutical University

抄録

We developed a physiologically based pharmacokinetic (PB-PK) model for spin-labeled drugs in animals and applied it for analyzing the decay curves of spin probes in the organs of mice as measured by multisite detection L-band ESR (MSD-LESR). The proposed method will be useful for not only understanding the PK features of nitroxyl radicals as spin probes but also developing spin-labeled drugs as a substitute for radioisotope-labeled drugs.

収録刊行物

  • Chemistry letters  

    Chemistry letters 35(10), 1170-1171, 2006-10-05 

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10018323449
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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