Intracerebroventricular Injection of L-Alanine Induces a Sedative Effect under an Acute Stressful Condition in Neonatal Chicks

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  • Kurauchi Isao
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University
  • Asechi Mari
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University
  • Tachibana Tetsuya
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University Present address : Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University
  • Han Li
    FANCL Research Institute
  • Hayamizu Kohsuke
    FANCL Research Institute
  • Denbow D. Michael
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University
  • Furuse Mitsuhiro
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University

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Pyruvate can be synthesized from amino acids such as L-alanine, L-serine and L-cysteine. Recently, we reported that intracerebroventricular (i.c.v.) injection of L-serine and L-cysteine attenuated acute stress in chicks. This fact implies that amino acid substrates for pyruvate play a sedative role in the brain. However, no information was available for L-alanine. To elucidate the central effect of L-alanine on stress responses, L-alanine (0.8μmol) or saline was administered i.c.v. just before exposure to social separation stress. The social separation stress increased spontaneous activity and vocalization of chicks, but these responses were attenuated by the i.c.v. injection of L-alanine. In conclusion, in addition to L-serine and L-cysteine, centrally administered L-alanine may be effective in attenuating anxiety induced by a psychological stressor.

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