Actions of imidacloprid, clothianidin and related neonicotinoids on nicotinic acetylcholine receptors of American cockroach neurons and their relationships with insecticidal potency

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  • Ihara Makoto
    Department of Applied Biological Chemistry, School of Agriculture, Kinki University
  • Brown Laurence A.
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford
  • Ishida Chiharu
    Department of Applied Biological Chemistry, School of Agriculture, Kinki University
  • Okuda Hiroshi
    Department of Applied Biological Chemistry, School of Agriculture, Kinki University
  • Sattelle David B.
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford
  • Matsuda Kazuhiko
    Department of Applied Biological Chemistry, School of Agriculture, Kinki University

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  • イミダクロプリド,クロチアニジンおよび関連するネオニコチノイドのワモンゴキブリの神経細胞に存在するニコチン性アセチルコリン受容体に対する作用と殺虫活性との関係

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Abstract

The actions of neonicotinoid insecticides on nicotinic acetylcholine receptors (nAChRs) in the terminal abdominal ganglion neurons of the American cockroach were investigated using whole-cell patch-clamp electrophysiology. Neonicotinoids possessing a nitromethylene group showed higher agonist affinity than the corresponding nitroimine analogues, whereas compounds with an acyclic guanidine moiety showed greater agonist efficacy than the corresponding cyclic compounds. Imidacloprid showed the lowest agonist efficacy of all neonicotinoids and low concentrations of imidacloprid attenuated acetylcholine-induced currents. However, such blocking actions were minimal with other neonicotinoids. The diverse actions of neonicotinoids on nAChRs, combined with target accessibility based on hydrophobicity, appears to account for their insecticidal potency on cockroaches measured in the presence of metabolic inhibitors. © Pesticide Science Society of Japan

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