アミノアシルtRNA合成酵素のX線結晶構造解析

  • 濡木 理
    東京工業大学大学院生命理工学研究科生命情報専攻

書誌事項

タイトル別名
  • X-ray Crystallography of Aminoacyl-tRNA Synthetases
  • ソウゴウ ホウコク アミノアシル tRNA ゴウセイ コウソ ノ Xセン ケッショウ コウゾウ カイセキ

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抄録

Aminoacyl-tRNA synthetases (aaRSs) catalyze ligation of their cognate transfer RNAs (tRNAs) with a specific amino acid, which guarantees the correct protein biosynthesis. The 20 aaRSs are divided into two classes based on the catalytic folds and reaction properties. Up to date, crystal structures of all the 20 members have been reported, and it's time to discuss the structure-function relationships of this enzyme family. Recent genome analyses provide a novel insight, which may unveil the molecular evolution of the 20 members.

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