NUMBER OF SPUTUM CULTURES BY MGIT SYSTEM NEEDED TO DIAGNOSE PULMONARY TUBERCULOSIS

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  • ITO Kunihiko
    Department of Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA)
  • AONO Akio
    Department of Clinical Laboratory,Fukujuji Hospital, JATA
  • YOSHIYAMA Takashi
    Department of Respiratory Medicine, Fukujuji Hospital, JATA
  • WADA Masako
    Department of Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA)
  • OGATA Hideo
    Department of Respiratory Medicine, Fukujuji Hospital, JATA

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  • 肺結核診断時に必要な液体培地による喀痰培養検査の回数
  • ハイケッカク シンダンジ ニ ヒツヨウ ナ エキタイバイチ ニ ヨル カクタンバイヨウ ケンサ ノ カイスウ

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Abstract

[Purpose] To study the number of sputum cultures by MGIT system (Becton-Dickinson) needed to diagnose pulmonary tuberculosis.<BR>[Object a nd Method] Prospective study of all patients who visited our hospital, and were strongly suspected of pulmonary tuberculosis during the period from Jan. 2002 to Sept. 2003. In these patients, 3 consecutive sputum cultures were done by both MGIT-system and egg-based Ogawa medium (1 slant).<BR>[Results] Altogether 290 cases of sputum-culture positive pulmonary tuberculosis were available for analysis. In 210 first-sputum-smear positive cases, incremental yield of 3rd sputum culture in 3 consecutive MGIT cultures was equal to or less than 1. 0% and 98. 1 % of culture positive cases were detected by 2 consecutive MGIT cultures. In 80 first-sputumsmear negative cases, incremental yield of 3rd sputum culture in 3 consecutive MGIT cultures was equal to or more than 5.0 %, and 90. 0% of culture positive cases were detected by 2 consecutive MGIT cultures. This detection rate was almost the same as the calculated detection rate (91. 4%) by 3 consecutive Ogawa (2 slant) cultures (previous standard method).<BR>[Conclusion] It was suggested that 2 consecutive sputum cultures by MGIT were sufficient to detect M. tuberculosis in first-sputum-smear positive cases, but 3 consecutive sputum cultures by MGIT were relatively useful in first-sputum-smear negative cases.

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