CLINICAL MANIFESTATION OF Q FEVER AND TUBERCULOSIS, SIMILARLY CAUSED BY INTRACELLULAR PARASITES

• WATANABE Akira

  Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University

Bibliographic Information

Other Title

• 細胞内寄生菌の臨床―結核とＱ熱―
• ダイ81カイ ニホン ケッカクビョウ ガッカイ ソウカイ カイチョウ コウエン サイボウ ナイ キセイキン ノ リンショウ ケッカク ト Q ネツ
• 結核とQ熱

Abstract

Q fever is a generic term for pneumonia, bronchitis, etc. caused by infection with Coxiella burnetii, a rickettsiarelated species of bacteria, in humans. Q-fever is a transient and acute febrile illness that takes a course similar to influenza, and its clinical picture greatly differs from that of tuberculosis that takes a chronic course. The reason for this is thought to be because the generation time of C. burnetii is extremely short (several tens of minutes) compare d with Mycobacterium tuberculosis, though those are similar intracellular parasites. Q fever is fourth- or fifth-ranked among the community-acquired pneumonias in the United States and Europe but has a good prognosis with 1-2% of mortality even in the cases that follow a natural course without treatment. Meanwhile, there is a chronic type that follows a protracted course or has a poor prognosis. Therefore, cases definitely diagnosed with Q fever or strongly suspected of Q fever should seek aggressive treatment. Q fever is definitely diagnosed by confirming significant increase in serum antibody titer, but the patients should be followed because in many cases it takes a long time before serum antibody titer increases. Beta-lactams are ineffective against C. burnetii, an obligate intracellular parasite. Although tetracyclines, macrolides, quinolones, rifampicin, etc. are used effectively in the treatment of Q fever, many cases appear to improve by beta-lactam administration because the illness often takes a natural course.

Journal

• Kekkaku(Tuberculosis)

  Kekkaku(Tuberculosis) 81 (8), 543-549, 2006

  JAPANESE SOCIETY FOR TUBERCULOSIS

Keywords

• Q fever
• Zoonosis
• Coxiella burnetii
• Intracellular parasite
• Atypical pneumonia

Details

• CRID: 1390282679976885120
• NII Article ID: 10018335732
• NII Book ID: AN00073442
• DOI: 10.11400/kekkaku1923.81.543
• ISSN: 18842410
• ISSN: 00229776
• NDL BIB ID: 8066589
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8066589
• Web Site: https://search.jamas.or.jp/link/ui/2006303668
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed