書誌事項
- タイトル別名
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- DETECTION OF rpoB MUTATIONS IN RIFAMPICIN-RESISTANT MYCOBACTERIUM KANSASII
- リファンピシン タイセイ Mycobacterium kansasii ニ オケル rpoB ヘンイ ノ カイメイ
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[Purpose] To detect rifampicin-resistant mutations in Mycobacter iumkansasii (M. kansasii).<BR>[Methods] We examined t he M. kansasii isolates from sputum of patients at National Hospital Organization Kinkichuo Chest Medical Center from January 1, 2001 to November 30, 2005 using drug-susceptibility testing, and analyzed 69-bp fragment of rpoB gene in rifampicin-resistant strains.<BR>[Results] Three strains from 314 isolates were de termined as rifampicin resistant using drug-susceptibility testing. Those strains showed a rise in minimum inhibitory concentration (MIC), and had the mutations in rpoB gene. These point mutations in codons 513 and 516 were common mutations found in rifampicin-resistant clinical isolates of M. tuberculosis. [Discussion] We verified the association between rpoB gene mutations and rifampicin resistance in M. kansasii.
収録刊行物
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- 結核
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結核 81 (7), 475-479, 2006
一般社団法人 日本結核病学会
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詳細情報
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- CRID
- 1390001204999460480
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- NII論文ID
- 10018335804
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- NII書誌ID
- AN00073442
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- ISSN
- 18842410
- 00229776
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- NDL書誌ID
- 8037387
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可