DETECTION OF rpoB MUTATIONS IN RIFAMPICIN-RESISTANT MYCOBACTERIUM KANSASII
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- YOSHIDA Shiomi
- Clinical Research Center
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- SUZUKI Katsuhiro
- Clinical Research Center
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- TSUYUGUCHI Kazunari
- Clinical Research Center
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- IWAMOTO Tomotada
- Kobe Institute of Health
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- TOMITA Motohisa
- Departmen1t of Clinical Laboratory
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- OKADA Masaji
- Clinical Research Center
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- SAKATANI Mitsunori
- Department of Respiratory Medicine, National Hospital Organization Kinki-chuo Chest Medical Center
Bibliographic Information
- Other Title
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- リファンピシン耐性Mycobacterium kansasiiにおけるrpoB変異の解明
- リファンピシン タイセイ Mycobacterium kansasii ニ オケル rpoB ヘンイ ノ カイメイ
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Abstract
[Purpose] To detect rifampicin-resistant mutations in Mycobacter iumkansasii (M. kansasii).<BR>[Methods] We examined t he M. kansasii isolates from sputum of patients at National Hospital Organization Kinkichuo Chest Medical Center from January 1, 2001 to November 30, 2005 using drug-susceptibility testing, and analyzed 69-bp fragment of rpoB gene in rifampicin-resistant strains.<BR>[Results] Three strains from 314 isolates were de termined as rifampicin resistant using drug-susceptibility testing. Those strains showed a rise in minimum inhibitory concentration (MIC), and had the mutations in rpoB gene. These point mutations in codons 513 and 516 were common mutations found in rifampicin-resistant clinical isolates of M. tuberculosis. [Discussion] We verified the association between rpoB gene mutations and rifampicin resistance in M. kansasii.
Journal
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- Kekkaku(Tuberculosis)
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Kekkaku(Tuberculosis) 81 (7), 475-479, 2006
JAPANESE SOCIETY FOR TUBERCULOSIS
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Keywords
Details 詳細情報について
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- CRID
- 1390001204999460480
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- NII Article ID
- 10018335804
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- NII Book ID
- AN00073442
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- ISSN
- 18842410
- 00229776
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- NDL BIB ID
- 8037387
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed