hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese

この論文にアクセスする

この論文をさがす

著者

    • HIGAKI Yasuki
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • HARA Megumi
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • ICHIBA Masayoshi
    • Department of Social and Environmental Medicine, Faculty of Medicine, Saga University
    • HORITA Mikako
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • EGUCHI Yuichiro
    • Department of Internal Medicine, Faculty of Medicine, Saga University
    • OZAKI Iwata
    • Department of Internal Medicine, Faculty of Medicine, Saga University
    • ONOHARA Shingo
    • Department of Internal Medicine, Saga Prefectural Hospital Koseikan
    • KAWAZOE Seiji
    • Department of Internal Medicine, Saga Prefectural Hospital Koseikan
    • KOIZUMI Shunzo
    • Department of General Medicine, Faculty of Medicine, Saga University
    • TANAKA Keitaro
    • Department of Preventive Medicine, Faculty of Medicine, Saga University

抄録

<b>BACKGROUND:</b> The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC).<br><b>METHODS:</b> We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC.<br><b>RESULTS:</b> Overall, the <i>hOGG1</i> genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69).<br><b>CONCLUTIONS:</b> These results suggest that the <i>hOGG1</i> Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.<br><i>J Epidemiol</i> 2006; 16 :233-239.

収録刊行物

  • Journal of epidemiology  

    Journal of epidemiology 16(6), 233-239, 2006-11-01 

    Japan Epidemiological Association

参考文献:  32件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10018347734
  • NII書誌ID(NCID)
    AA10952696
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09175040
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ