hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese
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<b>BACKGROUND:</b> The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC).<br><b>METHODS:</b> We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC.<br><b>RESULTS:</b> Overall, the <i>hOGG1</i> genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69).<br><b>CONCLUTIONS:</b> These results suggest that the <i>hOGG1</i> Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.<br><i>J Epidemiol</i> 2006; 16 :233-239.
- Journal of Epidemiology
Journal of Epidemiology 16(6), 233-239, 2006-11-01
Japan Epidemiological Association