hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese
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- Sakamoto Tatsuhiko
- Department of Preventive Medicine, Faculty of Medicine, Saga University.
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- Higaki Yasuki
- Department of Preventive Medicine, Faculty of Medicine, Saga University.
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- Hara Megumi
- Department of Preventive Medicine, Faculty of Medicine, Saga University.
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- Ichiba Masayoshi
- Department of Social and Environmental Medicine, Faculty of Medicine, Saga University.
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- Horita Mikako
- Department of Preventive Medicine, Faculty of Medicine, Saga University. Department of Social and Environmental Medicine, Faculty of Medicine, Saga University.
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- Mizuta Toshihiko
- Department of Internal Medicine, Faculty of Medicine, Saga University.
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- Eguchi Yuichiro
- Department of Internal Medicine, Faculty of Medicine, Saga University.
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- Yasutake Tsutomu
- Department of Internal Medicine, Faculty of Medicine, Saga University.
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- Ozaki Iwata
- Department of Internal Medicine, Faculty of Medicine, Saga University.
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- Yamamoto Kyosuke
- Department of Internal Medicine, Faculty of Medicine, Saga University.
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- Onohara Shingo
- Department of Internal Medicine, Saga Prefectural Hospital Koseikan.
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- Kawazoe Seiji
- Department of Internal Medicine, Saga Prefectural Hospital Koseikan.
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- Shigematsu Hirohisa
- Department of Internal Medicine, Saga Prefectural Hospital Koseikan.
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- Koizumi Shunzo
- Department of General Medicine, Faculty of Medicine, Saga University.
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- Tanaka Keitaro
- Department of Preventive Medicine, Faculty of Medicine, Saga University.
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BACKGROUND: The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC).<br>METHODS: We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC.<br>RESULTS: Overall, the hOGG1 genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69).<br>CONCLUTIONS: These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.<br>J Epidemiol 2006; 16 :233-239.
収録刊行物
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- Journal of Epidemiology
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Journal of Epidemiology 16 (6), 233-239, 2006
日本疫学会
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詳細情報 詳細情報について
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- CRID
- 1390001204473752064
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- NII論文ID
- 10018347734
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- NII書誌ID
- AA10952696
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- ISSN
- 13499092
- 09175040
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可