Impact of transporter-mediated drug absorption, distribution, elimination and drug interactions in antimicrobial chemotherapy

• Tsuji, Akira

抄録

金沢大学薬学部

金沢大学大学院自然科学研究科分子作用学

A comprehensive list of drug transporters has recently become available as a result of extensive genome analysis. Membrane transporters play important roles in determining the pharmacokinetic aspects of intestinal absorption, tissue distribution, and the urinary and biliary excretions of a wide variety of therapeutic drugs. The identification and characterization of transporters responsible for the transfer of nutrients and xenobiotics, including drugs, is expected to provide a scientific basis for understanding drug disposition, as well as the molecular mechanisms of drug-drug/drug-food/drug-protein interactions and inter-individual/inter-species differences. This review focuses on the influence of transporters on the pharmacokinetics of β-lactam antibiotics, new quinolones, and other antimicrobial agents, as well as focusing on the drug-drug interactions associated with transporter-mediated uptake from the small intestine and transporter-mediated elimination from the kidney and liver. © 2006 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.

収録刊行物

• Journal of Infection and Chemotherapy

  Journal of Infection and Chemotherapy 12 (5), 241-250, 2006-10-01

  Springer Verlag

キーワード

• β-lactam antibiotics
• Blood-brain barrier
• Efflux transporter
• Influx transporter
• New quinolones
• Pharmacokinetics

詳細情報

• CRID: 1050564285907311872
• NII論文ID: 10018348080
• NII書誌ID: AA11057978
• ISSN: 1341321X
• Web Site: http://hdl.handle.net/2297/3234
• Web Site: https://search.jamas.or.jp/link/ui/2007284206
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles