Glutamine Administration Enhances the Healing of Lung Parenchymal Injuries and Reduces Air Leakage in Rats

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著者

    • SANLI AYDIN
    • Department of Thoracic Surgery, Faculty of Medicine, Dokuz Eylul University
    • ONEN AHMET
    • Department of Thoracic Surgery, Faculty of Medicine, Dokuz Eylul University
    • SARIOGLU SULEN
    • Department of Pathology, Faculty of Medicine, Dokuz Eylul University
    • SIS BANU
    • Department of Pathology, Faculty of Medicine, Dokuz Eylul University
    • GUNELI ENSARI
    • Department of Animal Science Laboratory, Faculty of Medicine, Dokuz Eylul University
    • GOKCEN BANU
    • Department of Thoracic Surgery, Faculty of Medicine, Dokuz Eylul University
    • KARAPOLAT SAMI
    • Department of Thoracic Surgery, Faculty of Medicine, Dokuz Eylul University
    • ACIKEL UNAL
    • Department of Thoracic Surgery, Faculty of Medicine, Dokuz Eylul University

抄録

Beneficial effects of glutamine on wound healing are well known. Parenchymal injuries in the lung cause air leakage that resolves with wound healing. We aimed to determine the effect of glutamine on the healing of lung injuries. Wistar albino female rats were randomized in three groups. One group (control, <i>n</i> = 7) received intraperitoneal injection of 0.9% sodium chloride (1.5 ml /day), while other group (GLN, <i>n</i> = 7) received glutamine (1.5 g/kg/day), beginning two days prior to the operation for total four days. After thoracotomy, a lung parenchymal lesion was made with a scalpel in the right upper lobe. Only thoracotomy was performed to sham group (<i>n</i> = 4). Air leakage was observed in the isolated lungs of control group, but not GLN and sham groups, at 5 cm H<sub>2</sub>O of positive airway pressure (<i>p</i> < 0.001). The threshold of positive airway pressure for air leakage was 4.85 ± 0.37 and 19.42 ± 4.54 cm H<sub>2</sub>O for control and GLN groups, respectively (<i>p</i> < 0.001). For measurement of collagen content in the healing parenchyma, digital images were processed to calculate the stained area percentage (SAP). SAP for immature collagen, a marker for wound healing, was 0.36 ± 0.18% and 1.48 ± 0.83% (<i>p</i> = 0.02) in control and GLN groups, respectively, but no significant difference was noted in SAP for mature collagen. The grade of inflammation was not significantly different between control and GLN groups. We conclude that glutamine enhances lung parenchymal healing by increasing immature collagen secretion.

収録刊行物

  • THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE  

    THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 210(3), 239-245, 2006-11-01 

    Tohoku University Medical Press

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各種コード

  • NII論文ID(NAID)
    10018349773
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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