Essential Genes as Potential Targets of Antifungal Agents in Pathogenic Yeast Candida

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  • Miyakawa Yozo
    Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
  • Chibana Hiroji
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Uno Jun
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Mikami Yuzuru
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • Nakayama Hironobu
    Department of Chemistry and Biochemistry, Suzuka National College of Technology

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  • Ｃａｎｄｉｄａ属酵母に対する抗真菌剤標的候補としての必須遺伝子群の探索
  • Candidaゾク コウボ ニ タイスル コウシンキンザイ ヒョウテキ コウホ ト シテ ノ ヒッス イデンシグン ノ タンサク

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Abstract

An important point in the development of an antimicrobial agent is whether its target molecules are essential for growth of the microorganism. From this viewpoint, we focused attention on essential genes as potential targets of antifungal agents in the pathogenic yeast Candida. Here we introduce recent attempts for screening, identification, and characterization of essential genes from a haploid yeast Candida glabrata, using temperature-sensitive mutants. Our experimental results suggesting the essentiality of C. albicans PHO85, the homologue of which is known as a negative regulator of the PHO system and as a non-essential gene in Saccharomyces cerevisiae are also described.

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