The Effect of Dimethyl Sulfoxide (DMSO) on the Growth of Dermatophytes

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Dimethyl sulfoxide (DMSO) is frequently used as a solvent for antifungal drugs in various studies to determine their MICs. Reports on comparative evaluation of methods for the susceptibility testing of antifungal drugs have shown there is poor agreement among methods. Besides other factors which could cause variability in the results, one important factor might be the effect of DMSO on the growth of fungi. The effect of DMSO on the growth of some species of <i>Candida</i> has been reported in the literature. The present study aimed at determination of the effect of different concentrations of DMSO (0.125 to 10%) on the growth of dermatophytes by agar diffusion method. There was no growth of fungi in 10% DMSO, between 1.25 and 5% there was a rather linear dose-related inhibitory effect on the growth, significantly different from the controls, and below 1% there was a variable effect among the species. DMSO down to 0.25% significantly inhibited the growth of most strains of <i>M. canis</i>. The lower concentrations of DMSO, which apparently do not affect the growth of fungi, may potentiate the effect of antifungal drugs.

収録刊行物

  • 日本医真菌学会雑誌 = Japanese journal of medical mycology  

    日本医真菌学会雑誌 = Japanese journal of medical mycology 47(4), 313-318, 2006-10-31 

    The Japanese Society for Medical Mycology

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各種コード

  • NII論文ID(NAID)
    10018350418
  • NII書誌ID(NCID)
    AN10166867
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09164804
  • NDL 記事登録ID
    023253720
  • NDL 請求記号
    Z19-348
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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