A Case of Malignant Haemangioendothelioma with Thrombocytopenia

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  • KOMESU Mami
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus
  • KAWASAKI Kyoko
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus
  • HANNITA Yuko
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus
  • MARUNO Motoyoshi
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus
  • UESATO Hiroshi
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus
  • NONAKA Shigeo
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus
  • SHINHAMA Midori
    Division of Dermatology, Naha City Hospital
  • GUSHIKEN Hatsuo
    Division of Dermatology, Naha City Hospital

Bibliographic Information

Other Title
  • 血小板減少を来した悪性血管内皮細胞腫の１例
  • 症例 血小板減少を来した悪性血管内皮細胞腫の1例
  • ショウレイ ケッショウバン ゲンショウ オ キタシタ アクセイ ケッカン ナイヒ サイボウ シュ ノ 1レイ

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Abstract

We report a 71-years-old female patient diagnosed as malignant haemangioendothelioma, presented with purpuric skin lesions at first on her left side of scalp, later on tumor was started to appear since May, 2000. This patient was received both topical and systemic administration of IL-2 (interleukin-2) along with simultaneous radiotherapy since July 2000. After initiation of therapy, tumoral growth became sometime diminished, but purpuric skin lesions of the patient became more aggressive. She developed thrombocytopenia without any signs of disseminated intravascular coagulation (DIC). All medications were discontinued for remission of thrombocytopenia but it was persisted without splenomegaly, and absence of antibody against thrombocytes. The patient's purpuric skin lesions became progressive. We speculated that the etiology of persistent thrombocytopenia of this case might be related with excessive local supply of thrombocytes in the progressive tumoral skin lesions. As a consequence of the disease progression with other complications such as metastasis to bone and lung, pneumo-hemothorax and DIC, the patient deceased at about five months after treatment.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 68 (2), 158-161, 2006

    Western Division of Japanese Dermatological Association

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