A Case of Toxic Epidermal Necrolysis Initially Affecting the Skin Site of Radiation Therapy for an Intra-cranial Post-transplantation Lymphoma

  • TANOUE Toshihide
    Derpartment of Dermatology, Graduate School of Medical & Pharmaceutical Sciences, Kumamoto University
  • EGAWA Kiyofumi
    Derpartment of Dermatology, Graduate School of Medical & Pharmaceutical Sciences, Kumamoto University
  • FUKUSHIMA Satoshi
    Derpartment of Dermatology, Graduate School of Medical & Pharmaceutical Sciences, Kumamoto University
  • WAKASUGI Syoji
    Derpartment of Dermatology, Graduate School of Medical & Pharmaceutical Sciences, Kumamoto University
  • ONO Tomomichi
    Derpartment of Dermatology, Graduate School of Medical & Pharmaceutical Sciences, Kumamoto University
  • YOSHIDA Shinsuke
    Derpartment of Neurosurgery, Graduate School of Medical & Pharmaceutical Sciences, Kumamoto University
  • KOUCHI Masato
    Derpartment of Neurosurgery, Graduate School of Medical & Pharmaceutical Sciences, Kumamoto University
  • NISHI Kazuhiko
    Derpartment of Hemocatharsis, The University of Kumamoto Hospital

Bibliographic Information

Other Title
  • 頭蓋内Post-transplantation Lymphoma患者の放射線照射部皮膚に初発したTEN の1例
  • 症例 頭蓋内Post-transplantation Lymphoma患者の放射線照射部皮膚に初発したTENの1例
  • ショウレイ ズガイ ナイ Post transplantation Lymphoma カンジャ ノ ホウシャセン ショウシャブ ヒフ ニ ショハツ シタ TEN ノ 1レイ

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Abstract

We report a case of post-transplantation lymphoma (intra-cranial EBV-related malignant lymphoma) who developed toxic epidermal necrolysis (TEN) during concomitant phenobarbital administration and radiotherapy. The erythema exsudativum multiforme-like eruption first appeared on the site of radiation and extended to approximately 35% of the body surface. After stopping radiation therapy and all medications, including immunosuppressant, anticonvulsant, and diuretic drugs, treatment was successfully administered by systemic corticosteroids including semi-pulse therapy (500 mg of methylpredonisolone sodium succinate for 3 days).

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 68 (1), 46-50, 2006

    Western Division of Japanese Dermatological Association

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