Points to Consider on Missing Data へのコメント [in Japanese] Comments on Points to Consider on Missing Data [in Japanese]
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The "Point to Consider (PtC) on Missing Data" issued by EMEA implicitly postulates strict intention-to-treat analyses and discusses various methods for imputation of missing data, including parametric imputation methods. Imputation may not be relevant to situations after the occurrence of particular events such as a terminating event like death or clinical events that can largely alter the value of the response variable. Possibility of non-ignorable missing mechanisms when adopting parametric methods with ignorable assumptions is also discussed. Lastly, we stress the need for greater efforts in designing and monitoring clinical trials to prevent missing observations.
- Japanese Journal of Biometrics
Japanese Journal of Biometrics 27, S50-S54, 2006-09-30
The Biometric Society of Japan