STI571 for GIST
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- NAKANISHI Masayoshi
- Department of Surgery, Matsushita Memorial Hospital
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- NOGUCHI Akinori
- Department of Surgery, Matsushita Memorial Hospital
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- TAKESHITA Hiroki
- Department of Surgery, Matsushita Memorial Hospital
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- YAMAMOTO Yusuke
- Department of Surgery, Matsushita Memorial Hospital
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- ITO Tadao
- Department of Surgery, Matsushita Memorial Hospital
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- TANI Naoki
- Department of Surgery, Matsushita Memorial Hospital
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- SUGANUMA Yasushi
- Department of Surgery, Matsushita Memorial Hospital
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- YAMAGUCHI Masahide
- Department of Surgery, Matsushita Memorial Hospital
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- OKANO Shinji
- Department of Surgery, Matsushita Memorial Hospital
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- YAMANE Tetsuro
- Department of Surgery, Matsushita Memorial Hospital
Bibliographic Information
- Other Title
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- 再発性胃消化管間質性腫瘍(GIST)に対するメシル酸イマチニブによる治療
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Abstract
Since the effectiveness of STI571 for GIST was reported, therapy for GIST has changed markedly, and the disease has attracted attention. We have treated 19 patients with GIST since 2000 by 19 resections (local resection in 14 patients, total gastrectomy in 2 patients, distal gastrectomy in 2 patients, and hepatectomy in 1 patient), and administered STI571 to 5 patients with unresectable or recurrent GIST. Of these 5 patients, 2, 1, 1, and 1 had PR, SD, PD, and inevaluable disease, respectively, with a response rate of 50%. The disease was controllable in 80% of the patients. All patients had palpebral and crural edema as side effects, which were not severe, suggesting the safety of the drug. It is important to tailor therapy (STI571 or surgery) to the patient. <br>
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 103 (7), 819-826, 2006
The Japanese Society of Gastroenterology
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Details 詳細情報について
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- CRID
- 1390282681375334400
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- NII Article ID
- 10018364559
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- NII Book ID
- AN00192124
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- ISSN
- 13497693
- 04466586
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed