Effect of Statin on Restenosis after Radius Stent Implantation in Patients with Acute Coronary Syndrome

• Nishikawa Hiroaki

  Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

• Miura Shin-ichiro

  Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

• Shimomura Hideki

  Division of Cardiology, Fukuoka Tokusyukai Hospital, Fukuoka, Japan.

• Kawamura Akira

  Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

• Tsujita Kenichi

  Division of Cardiology, Fukuoka Tokusyukai Hospital, Fukuoka, Japan.

• Shirai Kazuyuki

  Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

• Matsuo Kunihiro

  Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

• Arai Hidekazu

  Division of Cardiology, Fukuoka Tokusyukai Hospital, Fukuoka, Japan.

• Saku Keijiro

  Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

Abstract

Despite reports that statin treatment reduces the rate of coronary restenosis with a balloon expandable stent, there is no evidence that statins affect the incidence of restenosis with a self-expanding Radius stent. Ninety-five patients with acute coronary syndrome who had been implanted with a Radius stent were classified into two groups: those with hyperlipidemia and initial statin treatment (statin group, n = 38) and those without statin treatment (comparative group, n = 57). At six months after stent implantation, the rate of coronary restenosis was significantly lower in the statin group (10.5%) than control group (28.1%) (p = 0.033), while there were no differences in morphology, maximal inflation presure or stent size between the two groups. Interestingly, there was no difference in the serum lipid profile between the two groups at the 6-month follow-up, although the statin group had a significantly lower rate of restenosis. In conclusion, initial statin therapy reduced the rate of coronary restenosis even when a Radius stent was implanted.

Journal

• Journal of Atherosclerosis and Thrombosis

  Journal of Atherosclerosis and Thrombosis 12 (6), 302-306, 2005

  Japan Atherosclerosis Society

Keywords

• Statin
• Radius stent
• Restenosis
• Acute coronary syndrome

Details

• CRID: 1390282679408069760
• NII Article ID: 10018365054
• NII Book ID: AA11018976
• DOI: 10.5551/jat.12.302
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://www.jstage.jst.go.jp/article/jat/12/6/12_6_302/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006280662
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed