Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000

• Arai Hidenori

  Department of Geriatric Medicine, Kyoto University School of Medicine, Kyoto, Japan.

• Yamamoto Akira

  National Cardiovascular Center, Osaka, Japan.

• Matsuzawa Yuji

  Department of Internal Medicine, Osaka University, Osaka, Japan.

• Saito Yasushi

  Department of Internal Medicine, Chiba University, Chiba, Japan.

• Yamada Nobuhiro

  Department of Internal Medicine, Tsukuba University, Ibaraki, Japan.

• Oikawa Shinichi

  Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

• Mabuchi Hiroshi

  Department of Internal Medicine, Kanazawa University, Ishikawa, Japan.

• Teramoto Tamio

  Department of Internal Medicine, Teikyo University, Tokyo, Japan.

• Sasaki Jun

  International University of Health and Welfare, Tochigi, Japan.

• Nakaya Noriaki

  Fussa Hospital, Tokyo, Japan.

• Itakura Hiroshige

  Ibaraki Christian University, Ibaraki, Japan.

• Ishikawa Yuichi

  Faculty of Health Sciences, Kobe University, Hyogo, Japan.

• Ouchi Yasuyoshi

  Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.

• Horibe Hiroshi

  Keisen Clinic, Tokyo, Japan.

• Egashira Tohru

  Department of Advanced Technology and Development, BML, Inc., Tokyo, Japan.

• Hattori Hiroaki

  Department of Advanced Technology and Development, BML, Inc., Tokyo, Japan.

• Shirahashi Nobuo

  Osaka City University Medical School, Osaka, Japan.

• Kita Toru

  Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Bibliographic Information

Other Title

• Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000 Serum Lipid Level Survey 2000 in Japan

Abstract

We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII</B> (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G → A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (−514 → CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.

Journal

• Journal of Atherosclerosis and Thrombosis

  Journal of Atherosclerosis and Thrombosis 12 (5), 240-250, 2005

  Japan Atherosclerosis Society

Keywords

• Hyperlipidemia
• Polymorphism
• Cholesterol ester transfer protein
• Lipoprotein lipase
• Triglyceride lipase
• Apolipoprotein CIII

Details

• CRID: 1390282679410456832
• NII Article ID: 130004444144
• NII Article ID: 10018365279
• NII Book ID: AA11018976
• DOI: 10.5551/jat.12.240
• COI: 1:CAS:528:DC%2BD28XnvVyrs7s%3D
• ISSN: 18803873
• ISSN: 13403478
• ISSN: http://id.crossref.org/issn/13403478
• PubMed: 16205020
• Web Site: https://www.jstage.jst.go.jp/article/jat/12/5/12_5_240/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007001981
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed