Relevance of Platelet-independent Effects of Aspirin to Its Salutary Effect in Atherosclerosis-related Events

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著者

    • KHAN Qaisar
    • Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences College of Medicine and the Central Arkansas Veterans Healthcare System
    • MEHTA Jawahar L.
    • Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences College of Medicine and the Central Arkansas Veterans Healthcare System

抄録

There is a close inter-relationship between oxidative stress, coagulation, inflammation, and smooth muscle cell growth as key components of atherosclerosis (Fig. 1). As an analgesic and anti-pyretic, aspirin has been in use for over a century. It acetylates the COX enzyme, irreversibly inhibiting the formation of prostaglandin. Its action on platelet TxA<SUB>2</SUB> has highlighted its role as an anti-thrombotic agent in cardiovascular patients. Over the last two decades, unique anti-inflammatory properties of aspirin not shared by other non-steroidals have been discovered. Aspirin biotransforms into salicylate, which has diverse but potent anti-inflammatory properties. As we strive to better understand the concepts of atherogenesis, chronic inflammation, oxidative stress, and endothelial activation, these novel effects of aspirin provide new insights as to how this wonder drug works. These effects of aspirin alter many, if not all, components of the atherogenesis cascade shown in Fig. 1.

収録刊行物

  • Journal of atherosclerosis and thrombosis  

    Journal of atherosclerosis and thrombosis 12(4), 185-190, 2005-08-25 

    Japan Atherosclerosis Society

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各種コード

  • NII論文ID(NAID)
    10018365465
  • NII書誌ID(NCID)
    AA11018976
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13403478
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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