HMG-CoA Reductase Inhibitors Suppress the Development and Progression of Carotid Artery Intimal-medial Thickening in Hypercholesterolemic Type 2 Diabetic Patients

• Takahashi Takeshi

  Diabetes Center, Kumamoto Medical Center, National Hospital Organization, Kumamoto, Japan.

• Ishii Norio

  Diabetes Center, Kumamoto Medical Center, National Hospital Organization, Kumamoto, Japan.

• Itai Kaori

  Diabetes Center, Kumamoto Medical Center, National Hospital Organization, Kumamoto, Japan.

• Goto Rieko

  Diabetes Center, Kumamoto Medical Center, National Hospital Organization, Kumamoto, Japan.

• Higashi Kiichiro

  Diabetes Center, Kumamoto Medical Center, National Hospital Organization, Kumamoto, Japan.

• Kobori Shozo

  Diabetes Center, Kumamoto Medical Center, National Hospital Organization, Kumamoto, Japan.

抄録

We reported previously that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (RIs) suppressed in vitro oxidized-low density lipoprotein-induced macrophage growth. To elucidate whether HMG-CoA RIs have anti-atherogenic effects separate from their cholesterol-lowering effect, total plasma levels of cholesterol in patients with type 2 diabetes mellitus (type 2 DM) and hypercholesterolemia were reduced to normal by one-year treatment with HMG-CoA RIs and intimal-medial thickness (IMT) of the common carotid arteries (CCA) was measured. Patients with type 2 DM and hypercholesterolemia received either pravastatin (n = 15) or simvastatin (n = 15), while another group of type 2 DM patients with normocholesterolemia did not receive these agents. IMT of the CCA was measured using Powervision SSA-370A, probe 7.5 Mhz. The mean IMT and the rate of increase of IMT were relatively elevated in the order of the simvastatin-treatment group, pravastatin-treatment group, and control group. Our results suggested that HMG-CoA RIs might have anti-atherogenic effects in addition to their cholesterol-lowering effect.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 12 (3), 149-153, 2005

  一般社団法人 日本動脈硬化学会

キーワード

• HMG-CoA reductase inhibitors
• Type 2 diabetes mellitus
• Intimal-medial thickness
• Common carotid artery

詳細情報

• CRID: 1390282679408007936
• NII論文ID: 130004444136
• NII論文ID: 10018365780
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.12.149
• COI: 1:CAS:528:DC%2BD28XnvVyrsbk%3D
• ISSN: 18803873
• ISSN: 13403478
• ISSN: http://id.crossref.org/issn/13403478
• PubMed: 16020915
• Web Site: https://www.jstage.jst.go.jp/article/jat/12/3/12_3_149/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006163205
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可