A Population-based Study of Arterial Stiffness Index in Relation to Cardiovascular Risk Factors
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- Sato Hideaki
- Department of General Medicine, School of Medicine, Kyorin University, Mitakashi, Tokyo, Japan.
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- Hayashi Junichi
- Department of General Medicine, School of Medicine, Kyorin University, Mitakashi, Tokyo, Japan.
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- Harashima Keiichiro
- Department of Physiology, School of Health, Kyorin University, Mitakashi, Tokyo, Japan.
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- Shimazu Hideaki
- Department of Physiology, School of Health, Kyorin University, Mitakashi, Tokyo, Japan.
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- Kitamoto Kiyoshi
- Department of General Medicine, School of Medicine, Kyorin University, Mitakashi, Tokyo, Japan.
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Abstract
We investigated the relation of arterial stiffness, considered an independent predictor of cardiovascular events, to cardiovascular risk factors in a population-based study of 1023 subjects. An Arterial Stiffness Index (ASI) was developed to evaluate arterial stiffness based on an analysis of the pulse wave amplitude pattern acquired from measurements of brachial blood pressure. In control subjects (n = 266) without any major risk factors, the ASI was 46 ± 11, and increased with age (r = 0.346). The ASI was significantly higher in women ranging from 50 to 54 years of age than in age-matched men. The ASI rose in correlation with the number of risk factors. Subjects with two risk factors showed a significantly higher ASI than those without any risk factors (54 ± 26 vs. 46 ± 11). The ASI was significantly increased in diabetic subjects with hypertension in comparison to those without hypertension. Furthermore, hyperlipidemic subjects with hypertension showed significantly higher values than those without hypertension. ASI could be a useful predictor of cardiovascular events in hypertensive subjects with multiple risk factors.
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 12 (3), 175-180, 2005
Japan Atherosclerosis Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679408001920
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- NII Article ID
- 130004444140
- 10018365904
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- NII Book ID
- AA11018976
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- COI
- 1:STN:280:DC%2BD2MzmtlGhuw%3D%3D
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- ISSN
- 18803873
- 13403478
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- PubMed
- 16020919
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed