Relationship between Insulin Resistance and Effect of Atorvastatin in Non-diabetic Subjects
Background: Although insulin resistance (IR) is present in non-diabetic subjects, it is unknown whether IR affects statin treatment. We assessed the relationship between IR and the changes of lipid profile in patients with hyperlipidemia treated by atorvastatin.<BR>Methods: Forty-four non-diabetic patients were included. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. We used the value of 2.5 as the threshold for IR.<BR>Results: High-density lipoprotein (HDL) cholesterol at baseline was lower and triglyceride (TG) at baseline was higher in the IR group than in the nonIR group (<I>p</I> < 0.05). Changes in all lipid measurements did not differ between the two groups. HOMA-IR was correlated with HDL cholesterol at baseline and at follow-up and correlated with TG at baseline and at follow-up (<I>r</I> = −0.40, <I>r</I> = −0.53, <I>r</I> = 0.38, <I>r</I> = 0.35, <I>p</I> < 0.01, respectively). However, HOMA-IR did not associate with changes in total cholesterol, low-density lipoprotein cholesterol, HDL cholesterol, and TG.<BR>Conclusion: The IR did not affect the degree of reduction in cholesterol by atorvastatin in non-diabetic subjects. The IR may influence hypertriglyceridemia greater than the effect of atorvastatin in non-diabetic subjects.
- Journal of atherosclerosis and thrombosis
Journal of atherosclerosis and thrombosis 12(1), 9-13, 2005-02-28
Japan Atherosclerosis Society