Hyper-homocysteinemia is Not a Main Feature of Juvenile Uncomplicated Type 1 Diabetes

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    • MELONI Gian Franco
    • Department of Pharmacology, Ginecology and Obstetrics, Pediatrics, University of Sassari
    • TONOLO Gian Carlo
    • Diabetology Unit, Department of Clinica Medica and Patologia Medica, University of Sassari
    • ZAPPACOSTA Bruno
    • Center for High Technology Research and Education in Biomedical Science, Catholic University
    • MUSUMECI Salvatore
    • Department of Pharmacology, Ginecology and Obstetrics, Pediatrics, University of Sassari


Total plasma homocysteine (tHcy) was measured by high pressure liquid chromatography (HPLC) method in 28 patients (12 females and 16 males) at the onset of type 1 diabetes mellitus (T1DM), 4 females during diabetes ketoacidosis (DKA) and 154 (68 females and 86 males) during follow-up. Serum folate, pyridoxal 5' phosphate (PLP) and Vitamin B12 (Vit B12) were also measured. Plasma tHcy levels were not found significantly different in T1DM patients known to have diabetes (males 9.2 ± 7.7 and females 7.0 ± 2.8 μmol/l) and in those who were newly diagnosed (males 9.7 ± 4.8 and females 7.16 ± 2.8 μmol/l) than in healthy controls (males 8.7 ± 3.5 and females 7.8 ± 2.55 μmol/l). Only a significant difference for sex was observed in known diabetes (<I>p</I> = 0.0281). Serum folate, PLP and Vit B12 were normal (12.6 ± 3.6 ng/ml, 20.11 ± 0.8 ng/ml and 416.7 ± 41.9 pg/ml) in all T1DM patients. Age significantly correlated with plasma tHcy. Only in 4 patients, studied during DKA, plasma tHcy was significantly lower (2.76 ± 1.33 μmol/l, <I>p</I> < 0.001) than the healthy controls.


  • The Journal of Japan Atherosclerosis Society  

    The Journal of Japan Atherosclerosis Society 12(1), 14-19, 2005-02-28 

    Japan Atherosclerosis Society

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