Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits

DOI Web Site PubMed 被引用文献8件 参考文献74件
  • Kurosawa Tohru
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha, Ltd., Kanagawa, Japan
  • Itoh Fumi
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha, Ltd., Kanagawa, Japan
  • Nozaki Aiko
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha, Ltd., Kanagawa, Japan
  • Nakano Yoshihisa
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha, Ltd., Kanagawa, Japan
  • Katsuda Shin-ichiro
    Department of Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan
  • Osakabe Naomi
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan
  • Tsubone Hirokazu
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
  • Kondo Kazuo
    Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan
  • Itakura Hiroshige
    Department of Food Science, Ibaraki Christian University, Ibaraki, Japan

この論文をさがす

抄録

We investigated the suppressive effect of cocoa powder (cacao polyphenol content: 7.8%) on atherosclerosis in a spontaneous familial hypercholesterolemic model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Six-month dietary administration of cocoa powder had no effects on body weight, hematology or blood chemistry parameters or a lipid profile in KHC rabbits. Antioxidative activity of low-density lipoprotein (LDL) was observed in the 2nd month and 3rd month of administration. Thiobarbituric acid reactive substances (TBARS), the marker of lipid peroxidation, in plasma were decreased in the cocoa powder treated group from the 2nd month of administration during the study period compared to that in the control group. The area of atherosclerotic lesions in th aorta was significantly smaller in the cocoa powder group (30.87%) than in the control (52.39%). Tissue cholesterol content also tended to decrease. Distensibility of the aortic wall was improved significantly in the cocoa powder treated group due to decreases in fatty streaks and intimal thickening compared to that in the control group. These results suggest that cocoa powder has suppressive effect on development of atherosclerotic lesions. We consider that antioxidative activity of polyphenols rich in cocoa powder may be a key factor for the anti-atherosclerotic effect.

収録刊行物

被引用文献 (8)*注記

もっと見る

参考文献 (74)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ