Characterization of the Expression of TLR2 (Toll-like Receptor 2) and TLR4 on Circulating Monocytes in Coronary Artery Disease

この論文にアクセスする

この論文をさがす

著者

    • ASHIDA Kazuhiro
    • Internal Medicine I, Medical Research Center, National Defense Medical College
    • MIYAZAKI Koji
    • Internal Medicine I, Medical Research Center, National Defense Medical College
    • TAKAYAMA Eiji
    • Department of Paracytology, Medical Research Center, National Defense Medical College
    • TSUJIMOTO Hironori
    • Division of Basic Traumalogy, Medical Research Center, National Defense Medical College
    • AYAORI Makoto
    • Internal Medicine I, Medical Research Center, National Defense Medical College
    • IWAMOTO Noriyuki
    • Internal Medicine I, Medical Research Center, National Defense Medical College
    • YONEMURA Astushi
    • Internal Medicine I, Medical Research Center, National Defense Medical College
    • ISODA Kikuo
    • Internal Medicine I, Medical Research Center, National Defense Medical College
    • HIRAIDE Hoshio
    • Division of Basic Traumalogy, Medical Research Center, National Defense Medical College
    • OHSUZU Fumitaka
    • Internal Medicine I, Medical Research Center, National Defense Medical College

抄録

TLRs are receptors involved in the recognition of pathogens by the innate immune system, and TLR2 and TLR4 play important roles in the activation of monocytes. A total of 105 consecutive patients who underwent coronary angiography comprised of 46 with stable effort angina (SA), 41 with unstable angina (UA), and 18 with no significant CAD (CNT) were enrolled. The baseline expression levels of TLR2 and TLR4 on monocytes in peripheral blood mononuclear cells (PBMCs) were determined by flow-cytometric analysis. Since TLR2 expression has been reported to be regulated by TLR4 signaling, we cultured PBMCs with or without lipopolysaccharide (LPS, 1 μg/ml). At baseline, TLR4 levels (mean of fluorescence intensity ) in SA (145 ± 58, <I>p</I> < 0.05) and UA (164 ± 65, <I>p</I> < 0.01) were higher than those in CNT (107 ± 37). As for TLR2, levels were higher in UA (108 ± 36, <I>p</I> < 0.05) than in SA (94 ± 18) and CNT (87 ± 22). After stimulation with LPS, TLR2 levels increased in SA but decreased in UA. In conclusions, TLR4 levels increased in both SA and UA. Monocytes in UA were characterized by elevated TLR2 levels and unresponsiveness of the TLR2 levels to TLR4 stimulation.

収録刊行物

  • Journal of atherosclerosis and thrombosis  

    Journal of atherosclerosis and thrombosis 12(1), 53-60, 2005-02-28 

    Japan Atherosclerosis Society

参考文献:  34件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

被引用文献:  2件

被引用文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10018366417
  • NII書誌ID(NCID)
    AA11018976
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13403478
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ