Unusual case of cutaneous T-cell lymphoma with a prominent reactive population of B lymphocytes.

DOI 9 References
  • Nozawa Yoshihiro
    Department of Pathology, School of Medicine, Fukushima Medical University
  • Tasaki Kazuhiro
    Department of Pathology, School of Medicine, Fukushima Medical University
  • Ohtsuka Mikio
    Department of Dermatology, School of Medicine, Fukushima Medical University
  • Iwatuki Keiji
    Department of Dermatology, School of Medicine, Fukushima Medical University
  • Tominaga Kunihiko
    Surgical Pathology Division, Takeda General Hospital
  • Abe Masafumi
    Department of Pathology, School of Medicine, Fukushima Medical University

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Abstract

A 58-year-old Japanese woman presented an eruption in the region of the back and the upper extremities, a subcutaneous nodule on the right breast, and a left cervical lymphadenopathy. The excision biopsy specimens, of a subcutaneous nodule and a lymph node, showed a vaguely nodular growth pattern comprising a small CD20+ IgD+ lymphocyte infiltrate around clusters of medium-sized or large CD3+ lymphoid cells, in which histological distinction between malignant lymphoma and reactive lymphoid hyperplasia was difficult. Southern-blot analysis revealed the presence of rearranged bands for the beta chain of the T-cell receptor, but not for the immunoglobulin heavy chain. The neoplastic cells were therefore identified to be of T-cell origin. This case represents an unusual cutaneous T-cell lymphoma with a prominent reactive population of B lymphocytes.

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