共通オッズ比を用いるＨａｒｄｙ‐Ｗｅｉｎｂｅｒｇ平衝の検証

• 大山 哲司

  久留米大学バイオ統計センター

• 吉村 公雄

  国立がんセンター研究所

• 柳川 堯

  久留米大学バイオ統計センター

書誌事項

タイトル別名

• Testing the Hardy-Weinberg Equilibrium Using Comon Odds Ratio
• 共通オッズ比を用いるHardy-Weinberg平衡の検証
• キョウツウ オッズヒ オ モチイル Hardy Weinberg ヘイコウ ノ ケンショウ

抄録

The problem of testing the Hardy-Weinberg equilibrium (HWE) when the data are stratified in several strata is considered. In previous methods, null hypothesis is that HWE holds and alternative hypothesis is that HWE does not hold. But these methods cannot test the HWE positively. Therefore, we formulate the test of the HWE as the problem of testing equivalence. Considering an odds ratio as the measure of disequilibrium, it is assumed that the ratio is common across strata. We propose two tests based on the trinomial distribution and quadrinomial distribution. It is shown that those tests are asymptotically equivalent. Those methods are applied to practical data for illustration.

収録刊行物

• 計量生物学

  計量生物学 27 (2), 97-108, 2006

  日本計量生物学会

キーワード

• testing equivalence
• trinomial distribution
• quadrinomial distribution
• conditional test
• Hardy-Weinberg equilibrium

詳細情報

• CRID: 1390001204370861568
• NII論文ID: 10018385903
• NII書誌ID: AA11591618
• DOI: 10.5691/jjb.27.97
• ISSN: 21856494
• ISSN: 09184430
• NDL書誌ID: 8596738
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8596738
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可