6-mercaptopurine により重症骨髄抑制をきたしたクローン病の1例  [in Japanese] A case report : Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient  [in Japanese]

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A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohns disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/μ<i>l</i>), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.<br>


  • Nippon Shokakibyo Gakkai Zasshi  

    Nippon Shokakibyo Gakkai Zasshi 103(9), 1044-1049, 2006-09-05 

    The Japanese Society of Gastroenterology

References:  14

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