HBe抗原陰性B型慢性肝炎患者におけるラミブジン投与中止時期についての検討 Timing of withdrawal of lamivudine treatment for HBeAg-negative chronic hepatitis B patients

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著者

    • 葛下 典由 KUZUSHITA Noriyoshi
    • 国立病院機構大阪医療センター消化器科 Department of Gastroenterology, National Hospital Organization, Osaka National Hospital
    • 三善 英知 MIYOSHI Eiji
    • 大阪大学大学院医学系研究科生化学 Department of Biochemistry, Osaka University Graduate School of Medicine
    • 田村 信司 TAMURA Shinji
    • 大阪大学大学院医学系研究科消化器内科学 Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine
    • 林 紀夫 HAYASHI Norio
    • 大阪大学大学院医学系研究科消化器内科学 Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine

抄録

We studied the timing of withdrawal of lamivudine administration for HBe Ag-negative chronic patients. The amount of serum HBV DNA was measured using the Amplicor HBV monitor (AM) and the Real-time Detection direct (RTD-direct). All values became less than 2.6 log copies/m<i>l</i> according to the AM method after administration. Five of 16 patients were found to have no HBV according to the RTD-direct (less than 1.0 log copies/m<i>l</i>). Thus, withdrawal of administration was attempted for these five patients. After the withdrawal, the viral load and ALT levels had increased in all patients. These results showed the difficulty of withdrawing lamivudine administration from HBe Ag-negative chronic patients, even though they have very low viral load in serum by the treatment.<br>

収録刊行物

  • 肝臓 = ACTA HEPATOLOGICA JAPONICA  

    肝臓 = ACTA HEPATOLOGICA JAPONICA 47(11), 516-517, 2006-11-25 

    The Japan Society of Hepatology

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各種コード

  • NII論文ID(NAID)
    10018390036
  • NII書誌ID(NCID)
    AN00047770
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04514203
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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