LDL cholesterol と HCV core region はC型慢性肝炎に対する Peginterferon/Ribavirin 併用療法の重要な治療前効果予測因子である Low density lipoprotein cholesterol levels and amino acid substitutions in HCV core region are important pretreatment predictors of response to treatment with peginterferon plus ribavirin in Japanese patients with chronic hepatitis C

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We evaluated 130 consecutive Japanese adults of HCV genotype 1b who received treatment with peginterferon (PEG-IFN) plus ribavirin (RBV) for 48 weeks, to investigate the pretreatment predictive factors of early virologic response (EVR) and sustained virological response (SVR). 75% of patients could achieve EVR, and 45% were SVR. Multivariate analysis identified low density lipoprotein cholesterol (LDL-C) (≥86mg/d<i>l</i>) and amino acid (aa) substitutions in HCV core region (Double wild type; arginine at aa 70 and leucine at aa 91) as independent and significant determinants of EVR. Furthermore, multivariate analysis identified LDL-C (≥86mg/d<i>l</i>), aa substitutions in core region (Double wild type), gender (male), ICG R15 (<10%), AST (<60IU/<i>l</i>) as determinants of SVR. In conclusion, LDL-C and aa substitutions in core region are important pretreatment predictors of response to treatment with PEG-IFN plus RBV in Japanese patients infected with genotype 1b.<br>

収録刊行物

  • 肝臓 = ACTA HEPATOLOGICA JAPONICA  

    肝臓 = ACTA HEPATOLOGICA JAPONICA 47(9), 450-451, 2006-09-25 

    The Japan Society of Hepatology

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各種コード

  • NII論文ID(NAID)
    10018390259
  • NII書誌ID(NCID)
    AN00047770
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04514203
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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