A CASE OF SPONTANEOUS COMPLETE NECROSIS OF HEPATOCELLULAR CARCINOMA

  • SHIBUYA Kazuto
    Second Department of Surgery, Toyama Medical and Pharmaceutical University School of Medicine
  • BANDO Tadashi
    Second Department of Surgery, Toyama Medical and Pharmaceutical University School of Medicine
  • ONISHI Yasuharu
    Second Department of Surgery, Toyama Medical and Pharmaceutical University School of Medicine
  • NAGATA Takuya
    Second Department of Surgery, Toyama Medical and Pharmaceutical University School of Medicine
  • YAMAGISHI Fuminori
    Second Department of Surgery, Toyama Medical and Pharmaceutical University School of Medicine
  • TSUKADA Kazuhiro
    Second Department of Surgery, Toyama Medical and Pharmaceutical University School of Medicine

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  • 自然壊死をきたした肝細胞癌と考えられる1例

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Abstract

We reported a rare case of hepatocellular carcinoma (HCC) with spontaneous complete necrosis. A 71-year-old man who was followed for chronic hepatitis type C was admitted to our hospital because a tumor was pointed out at the anterior-inferior segment of the liver (S5). Under a diagnosis of HCC, the partial resection of the liver was performed. The lesion was a yellowish mass, measuring 1.7×1.0cm, with a capsule. Histopathologically, the nodule was surrounded with a thick fibrous tissue, and fell into complete necrosis. No viable cancer cells were recognized. Finally, this case was considered to be spontaneous complete necrosis of HCC, because Ag stain of the resected specimen demonstrated the remains of reticulin fiber, and immunohistochemistry revealed a positive finding of antihepatocyte antibody. It was supposed that a decline of arterial feeding due to the endothelial injury by angiography or an immunological reaction may be associated with a mechanism of spontanenous complete necrosis of HCC. Only six cases of spontaneous complete necrosis of HCC were found in the literature.

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